The website aims to publish all wordlists, big and small, on the internet, making it much easier to … I’m trying to understand the motivation for writing an article like that. Yet when we measure time in years rather than hours, we can see that most of the real … Here are some examples of vision statements: 1. You can be absolutely certain that senior management is the ONLY part of a company which will never be outsourced. I have to think that these were apocryphal tales spread by consultants, who wanted to spread fear and doubt in order to be hired for their own fearsome planning abilities. Extract from : « Daily Thoughts » by Charles Kingsley; He saw how baseless his hope had been, and he exonerated her from all blame. SmallMoleculeGuy: Diversifying out of small molecules into “biopharmaceuticals” increases portfolio risk, rather than reducing it. And all our yesterdays have lighted fools (Act 4 Scene 1, Lines 147). We are such stuff As dreams are made on, and our little life Is rounded with a sleep. Although Income tax is low by international standards property taxes are formidable and the shop assistant on 40 HK$ an hour serving you your pack of dried oversweetened noodles cannot ever dream of affording to move beyond their crumbling backstreet room that they share with five other prematurely aging exhausted individuals – all sleeping in shifts. I certainly never saw the slightest interest in developing anyone. Interesting that my attempts at researching inflammation got me here in the first place. We are such stuff As dreams are made on, and our little life Is rounded with a sleep. And, like this insubstantial pageant faded, Leave not a rack behind. "Our wonder and astonishment" Shakespeare = "Varázslatod örök csodánk" Nyíregyháza, 2016,67-76. Essential Meaning: Power is an illusion. Personally, I’ve lost count since I started work in 1989 of the various revamps, overhauls, re-orgs, re-alignments, and Big Total Changes I’ve seen. Asked by shemeka j #303365 on 3/26/2013 1:43 PM Last updated by Aslan on 3/26/2013 2:27 PM Answers 1 Add Yours. He tries to calm the startled couple by explaining, somewhat off the point, that the \"revels\" (performance) they've witnessed were simply an illusion, bound sooner or later to melt into \"thin air\"a phrase he coins. Furthermore, within our industry there is a growing focus on biological approaches such as monoclonal antibodies or cell and gene therapy to target very specific patient phenotypes, stimulated by our expanded knowledge of the human genome. Only one link in the chain of destiny can be handled at a time.”, Since we’re at it, Yogi Berra also has a good one: “It’s tough to make predictions, especially about the future.”. There are a few trials involving anti TNF treatments for RSD. To the last syllable of recorded time; Baseless fabric means "substance without foundation," which poetically translates in this context to an artifice or contrivance. OK, so medicinal chemistry has been down-sizing for 15 years. The "baseless fabric," I argue, alludes to the immaterial nature of the quantized fields that couple to compose this "vision." Who’s it for? Or at least all big, overarching, multiyear planning. It seems to me that you have two choices: Combined with the word vision (here in its denotation as "supernatural or imaginary appearance"), referring to the pageant, it continues the theme of theatrical magic. IKEA:To create a better everyday life for the many people 3. Disney:To make people happy 2. Encyclo.co.uk, online since 2007, is a search engine for English meanings and definitions. Which yet survive, stamped on these lifeless things, Who said: “Two vast and trunkless legs of stone Steve, would you loan me $250m while I get started? Some unsolicited advice to pharma investors…if the company CEO is an economist, accountant, sales guy….wannabe UK House of Lords aspirant, hedge-fund manager, ex-McKinsey guy…store your money under the mattress. Most people don’t want to be entrepreneurs, let alone people who have spent years being (mostly) trained in an environment that is not exactly similar to the environment of running a company (that either selects them out or requires the rarer set of people having traits consistent with both environments). Very few Big Strategies at a given company last for ten years, no matter who’s in charge. Regarding Japanese long-term planning and the 80s having dealt with Japanese companies back then it did seem their attitudes where more compatible to realistic drug development timelines than those becoming predominate at US and even EU pharma. Not long ago, almost all of R&D exited the North Carolina site at RTP. Base"less, a. We are such stuff As dreams are made on, and our little life Is rounded with a sleep. If I had more than the gift of gab, perhaps esp….I’d have become my own chemist years back, before the RSD and all, ya’ll. Might that happen…well GSK is looking for a new (hopefully experienced) CEO to replace Sir Andy Witty, and there then is no way to know what a new regime might bring! It’s basically an “it sucks to be a chemist these days, but I’m doing the best I can” kind of article. For example, in 2015, one third of new drugs approved in the US by the Food and Drug Administration (FDA) were antibodies, peptides or enzymes, compared with about a quarter in 2014 (Ref #3 C&EN). -beginning to be convinced that contemporary molecule-metric med-chem was beginning to turn into a cargo-cult with Lipinski as it’s patriarch. None of it sounds particularly bad on paper, but a person of cynical bent would note that sounding good on paper is a major design feature of all these things. Also, “The best lack all conviction while the worst are full of passionate intensity” might be relevant here. Sir, I am vex'd; Any surprises progress is so slow? Why would such people even be looking at pharma considering the layoffs that have been taking place at regular intervals for years? It is not yet 20 years since Hong Kong was handed back to China, yet many of the old symbols of British rule have entirely faded. Hardly anyone in biotech becomes an entrepreneur before they’re in their 30’s or 40’s; it’s not like IT where you can start young. Near them, on the sand, These our actors, As I foretold you, were all spirits and Are melted into air, into thin air: And, like the baseless fabric of this vision, The cloud-capp’d towers, the gorgeous palaces, The solemn temples, the great globe itself, Yea, all which it inherit, shall dissolve And, like this insubstantial pageant faded, Leave not a rack behind. The site in Verona Italy was sold; many people were dismissed from jobs immediately, and more over time. Then, how would a proteolytic enzyme work? A three to seven day tour of Hong Kong is still the most frequent way those living in rural China see the “outside world”. Sir Andrew and his team have been attempting, with evident success, to de-risk the company by broadening revenue streams so that biologicals /vaccines, alongside small molecule,s have become important drivers of company sales. 401Ks and CEO windfalls all sound nice….I’d like to be able to walk past 2pm every day. And, like the baseless fabric of this vision, The cloud-capp’d towers, the gorgeous palaces, The solemn temples, the great globe itself, Yea, all which it inherit, shall dissolve, And, like this insubstantial pageant faded, Leave not a rack behind. And all those Corporate Vice Presidents of Quality, Medical and Sales VPs all got away scott-free with millions in bonuses. Philip Swain, a patent and trademark agent and the owner of IPSIS Inc., says, ‘As an entrepreneur and business owner there is little work-life balance. There is a quote from Macbeth (Act 5, scene 5) that may possibly be appropriate: “To-morrow, and to-morrow, and to-morrow, high school science tells you they are broken down in the stomach. Another one from the same source and that would seem to hit the mark: “It is a mistake to look too far ahead. -less likely to take the level of bullsh*t I put up with in med chem roles Good idea in theory… but difficult in practice. Just change your username to Sharknado. Is rounded with a sleep. At the end of the day, the drug discovery industry is disregarding the contributions of a motivated, talented and experienced sizable group of colleagues, who provide a unique perspective (at the molecular level) without which success is much less likely and more random. I recall a ‘Great Expectations’ initiative and somebody making the observation that the novel of the same name started among tombstones. I have no wish, however, to see you buoyed up by a baseless optimism. And like the baseless fabric of this vision, The cloud-capped towers, the gorgeous palaces, The solemn temples, the great globe itself, Yea, all which it inherit, shall dissolve, And, like this insubstantial pageant faded, Leave not a rack behind. It will lose less value. Some proteolytic enzymes are quite tough (so they don’t digest themselves when in concentrated form), so it might survive some digesting enzymes. Let’s see how that one works out. But once you’ve done it you wonder why you ever thought being just another cog in a wheel was a life worth living. Answered by Aslan on 3/26/2013 2:27 PM He is saying that the illusion he has created isn't real hence "baseless fabric". I hope you are all doing well during this pandemic. I do, however, give the author credit for this ending: Ultimately, however, the success of the model will be judged by the destination, which in our industry tends to be some 10 years after the medicinal chemistry costs are spent. We are such stuff As dreams are made on, and our little life Is … We are such stuff As dreams are made on, and our little life Is rounded with a sleep. The lifeblood of pharma is now in small companies. So, some of them may have been laid off (according to you, I can’t confirm it), but some excellent ones have arrived too. By 2010, those of us who were fortunate enough to be working all were scattered to different companies entirely, and the buildings we we’d been working in didn’t even belong to the company any more. We are such stuff As dreams are made on; and our little life Is rounded with a sleep. But let’s not offend those grinning HR types with our negative thoughts. And then is heard no more. The Japanese I interacted with expressed interest was in quality and sustainability that was better overall in the long-term than grabbing a quick buck and although definitely concerned appeared to be much less frantic when projects ran into unpredictable hurdles. These our actors, as I foretold you, were all spirits and are melted into air, into thin air; and like the baseless fabric of this vision, the cloud-capped towers, the gorgeous palaces, the solemn temples, the great globe itself, ye all which it inherit, shall dissolve, and, like this insubstantial pageant faded, leave not a rack behind. There’s a huge opportunity for some smart chemists to join the cancer immunotherapy revolution – figure out drugs that block Tregs, MDSC, Bregs and other immune suppressing cell types and/or drugs that switch M2 macrophages to M1, etc. [1913 Webster] 5. The world had other ideas, at least for us. The hand that mocked them and the heart that fed: The Baseless Fabric of This Vision : Mark Twain\u27s The Mysterious Stranger, a Nineteenth-Century Lyrical Novel. However, the story of “biopharm” does sound so sweet at those Wall Street analyst meetings…. Anyway, I had a wonderful year overthere, so even if the “best chemists” are gone, those left are still excellent and I learnt a lot ! y (vĭzh′ə-nĕr′ē) adj. We are such stuff As dreams are made on; and our little life Is … And, like the baseless fabric of a vision, Leave not one wreck behind." Sir, I am vexed. 152 The cloud-capp'd towers, the gorgeous palaces, ... played the Jack: done a mean trick. Existing in imagination only; imaginary. These are exciting times at GSK generally where, after a period of change and uncertainty, the overall management strategy is really starting to pay dividends. And like the baseless fabric of this vision, The cloud-capped towers, the gorgeous palaces, The solemn temples, the great globe itself, Ye all which it inherit, shall dissolve, And like this insubstantial pageant faded, Leave not a rack behind. I think it is important to put those statements into a broader context. Why bother? We are such stuff As dreams are made on, and our little life Is rounded with a sleep. The word rendered "burned up," like the word just before used and rendered "fervent heat" - a word of the same origin, but here intensive - means that they will undergo such a change as fire will produce; not, necessarily, that the matter composing them will be annihilated. However firm they appear to be, as though they might outlast the centuries themselves, yet the things which are seen are temporal, and like the baseless fabric of a vision, they shall all melt into thin air, and pass away. Ironically, you attempt to blame embittered former employees for stirring up bad reputation for the company, but your constant attempts to defend corporate GSK at the first mention of anything negative really shows how embittered and thin-skinned the management there is. 199. "THE BASELESS FABRIC OF THIS VISION": EXPECTATION, ILLUSION, AND DREAM IN CONRAD'S VICTORY Patricia M. Ho wis on University of King's College Questions about illusion—about how it may relate to what we perceive as "reality," and about its pervasiveness in human life and relationships—surface throughout Conrad's work, and in Victory * too many to count. The revelation from God had two purposes. I mean, how idiotic would you have to be to seriously attempt any useful strategy over that time span? Annonie: There were plenty shenanigans with Paxil and Avandia, way before Steve Nissen of Cleveland Clinic came up with his meta-analysis. Avon:To be the company that best understands and satisfies the product, service an… It is not obvious and the promoters of serrapeptase do not offer a mechanism. “Head of Respiratory Therapy Area and GSK’s Chief Chemist”. Having worked there for almost 20 years, the current management at GSK has success removed all of the best chemists (as judged by actually getting a drug to market), virtually everyone there who had any success in the last 15 years was laid off or treated so badly that they left. Hong Kong claims to be the international city of Asia, but the reality is that most of its population do not even speak Chinese, let alone English. Perhaps I should have titled the blog post that I’ve linked as the URL for this comment, “The Autumn Of The Patriarch”? Yea, all which it inherit, shall dissolve, It’s not trying to hide the situation, though (links added for the original references in the manuscript): The number of scientists employed in pharmaceutical R&D has decreased substantially over the past decade as a result of mergers, acquisitions and general economic constraint. Better off buying snake oil. Other than raw diets with no red meat, any other suggestions for meaningful ways to immediately go about reducing inflammation? Login, Tel: +0044 203 807 9205 / +00357 222 56381. And there’s the problem. Too bad most pharma leaders cannot see that…. We are such stuff. 1. How to use visionless in a sentence. Why did he do this? Keep thinking up new titles, and keep reprinting the name boards on offices…. As a great man once said, “success is the ability to go from one failure to another with no loss of enthusiasm.”, Yep – full marks. Of course the author would discuss the loss of jobs in the UK because it is under his nose every day. And like the baseless fabric of this vision, The cloud-capp’d tow’rs, the gorgeous palaces, The solemn temples, the great globe itself, Yea, all which it inherit, shall dissolve, And, like this insubstantial pageant faded, Leave not a rack behind. At least the “flex chem” model has for the time being stabilized medchem layoffs, though ironically it goes full circle to the pre-DPU pipeline structure. Even taxi drivers are almost entirely monolingual and Hong Kong’s reputed international cuisine barely ranges outside the sickly sweet and bland Cantonese diet. This is the most baseless hallucination that ever visited the brain of a genial optimist. What we see in this article is a plan to put choice two into operation. We can therefore reasonably assume that the number of medicinal chemists in the pharmaceutical industry in the UK has decreased by about a third since 2007. The way to dusty death. “The Baseless Fabric of this Vision” The Poetics of Space in The Tempest Marcell GELLÉRT Eötvös Loránd University Department of English Studies gellert_m@yahoo.co.uk Abstract. The baseless fabric of a vision, then, shall furnish my theme--chosen with apologies and regrets instead of the more limited field of pretty Polly's small talk. I assume most readers consider this the correct one? Perhaps if GSK actually produced any new drugs rather than lots of “embittered former employees”, then GSK might deserve a bit more respect? Extract from : « A Spoil of Office » by Hamlin Garland; Witchcraft is one of the most baseless, absurd, disgusting and silly of all the humbugs. Such a wonderful idea to put biologist and chemists at the same bench, moreover if you introduce the “hot bench” system… ). Investing in chemistry talent is an important part of our strategy to reduce the high levels of drug discovery attrition which have been so problematical within our industry. Will it work or even be given time to work – who knows. Many of those with hard earned savings are lured onto such tours by their cheapness – just 700 RMB (85 euros) – little realizing what is in store for them as they are herded from one tacky jewelry and souvenir dealer to the next and locked in underground rooms until they buy the overpriced goods forced upon them. So I really have to doubt if anyone has ever seen a consistent large-scale strategy through in this business for ten years under modern conditions. Unfortunately, not able to see the article without paying, and doubtful it’s worth it. We are such stuff As dreams are made on, and our little life Is rounded with a sleep. Now I understand Property Forecast Index…. Even if the overall number of chemists has decreased, the quality and productivity certainly have not. An editorially independent blog from the publishers of Science Translational Medicine. British Broadcasting Company (BBC):To be the most creative organization in the world 4. That struts and frets his hour upon the stage, I am not sure if these differences remains today (as globally patience in business is rare commodity) or even if back then was a part of a culture mask used to disguise their true disappointments however it is more comfortable working in a place or with people who did express understanding and appreciate for how long things took and the many uncertainties involved in a new drug . Stand in the desert. We are such stuff As dreams are made on, and our little life Is … Alas, all planning! If you’re going to spin BS publicly at least be original don’t rehash propaganda circa 2008. It is a tale As for retirement savings, many of us were matched in company stock, which basically wiped out a lot of non-diversifiable portfolio holdings. The talk of all these long-term plans brought to mind another instance where time triumphed over similarly ambitious claims. © 2020 American Association for the Advancement of Science. Instead of whining, take a risk and become entrepreneurs. Even in a tight jobs market the “very best” people tend to get multiple offers. And, like the baseless fabric of this vision, The cloud-capp'd towers, the gorgeous palaces, The solemn temples, the great globe itself, Ye all which it inherit, shall dissolve And, like this insubstantial pageant faded, Leave not a rack behind. For younger readers this was what was done in the past when the industry was growing, and succession planning could be left to take care of itself. While the other businesses in consumer and vaccines are doing OK, the previous decisions to sell BW’s consumer products back in 1996 now appears to have been a terrible idea, as does some other BW and Glaxo older compounds sold off, which eventually ended up at Turing and other places. see: https://en.wikipedia.org/wiki/Tenth_five-year_plan_(Soviet_Union). Evidence: And, like the baseless fabric of this vision, The cloud-capp’d towers, the gorgeous palaces, The solemn temples, the great globe itself, Ye all which it inherit, shall dissolve And, like this insubstantial pageant faded, Leave not a rack behind” (Shakespeare). Biomolecules have infinitely more complicated probability of success calculations due to constraints and risks in stability, drug delivery issues, immunogenicity etc etc. Without a base; having no foundation or support. As dreams are made on; and our little life. 4. a. Another word for baseless. 152 The cloud-capp'd towers, the gorgeous palaces, 153 The solemn temples, the great globe itself, 153. the great globe itself: all the world. Home » News Flash » The baseless fabric of this vision. Google Marty Freed and Zarifa in the NY Times to see excerpts from internal emails. Do nothing and thus plan, by default, to exit small molecule drug discovery over the next 15-20 years. At least get your fact right. “And like the baseless fabric of this vision, But, I agree with you, and many people in R&D too, the current management is hard to understand. The way to check would be to pick any given year, and then go back ten years and look at the slide decks and management presentations, asking yourself “Do these artifacts bear any resemblance at all to what really happened?” Ten years is a good estimate for the amount of time you have to wait to see effects downstream in the clinic and in approvals, but that’s an awfully long time for a PowerPoint slide deck to remain relevant. As dreams are made on, and our little life. The paper attempts to survey Shakespeare’s “new world” of the stage in search of creative correspondences between the diverse devices of a dramatic reform It has a very classic TV feel with a theme song that could have been pulled right out of the 1950s. ‘My name is Ozymandias, king of kings: --Locke. What I am sure of is that some credit must be due for not just settling for option 1. 3. a. ‘Murica, y’all! Find more ways to say baseless, along with related words, antonyms and example phrases at Thesaurus.com, the world's most trusted free thesaurus. And like the baseless fabric of a vision, Leave not a rack behind. There’s a big world out there. Despite what a few embittered former employees might say, the company has finally got its mojo back! And like the baseless fabric of this vision, The cloud-capp'd tow'rs, the gorgeous palaces, The solemn temples, the great globe itself, Yea, all which it inherit, shall dissolve, And, like this insubstantial pageant faded, Leave not a rack behind. And, like the baseless fabric of this vision,/ The cloud-capp'd towers, the gorgeous palaces,/ The solemn temples, the great globe itself, /Yea, all which it shall inherit, shall dissolve." They’ve even had some success, for example, with solar power. And, like the baseless fabric of this vision, The cloud-capp'd towers, the gorgeous palaces, The solemn temples, the great globe itself, Ye all which it inherit, shall dissolve. And, like this insubstantial pageant faded, Some peptides can get into the gut-associated lymphoid tissue though mostly after partial digestion – this is how oral vaccines work. In this seat of “free trade” and island of much prized “democracy” the authorities have responded to the complaints of local residents that baby milk was being bought up in large quantities by Chinese tourists because of health scares back home by banning its export – with heavy fines and even imprisonment for offenders. This management team at GSK has made some amazingly crappy decisions and deserves to be fired. The “baseless fabric of this vision” of “cloud capped towers” may immediately refer to the painted sets contained within the “great globe itself,” the name of Shakespeare’s theater. Yet the elected representatives have done little to curb the practice of luring Chinese villagers to the bright lights, taking the little money that they have and making them despise all that Hong Kong stands for. Another word for baseless. When I got to the Wonder Drug Factory in 1997, all the ID cards carried the logo “Vision 2010!”, which was the company’s Seldon Plan for becoming a mighty force by that distant year. Characterized by or given to apparitions, prophecies, or revelations. Any idea when I might get a drug or two (not the 5 that I take now which are worthless for what it’s worth) that will enable me to walk without feeling like I’m on fire, the wind is out to get me, or I am getting stung by 30 really pissed off hornets all at once? As dreams are made on, and our little life. Tell that its sculptor well those passions read A VIHAR (THE TEMPEST) Gellért Marcell: ”Suiting 'the action to the word, the word to the action': Staging the Mind in Shakespeare's Hamlet and The Tempest” in: Kiss, Zsuzsánna (szerk.) Combined with the word vision (here in its denotation as "supernatural or imaginary appearance"), referring to the pageant, it continues the theme of theatrical magic. Told by an idiot, full of sound and fury, Half sunk, a shattered visage lies, whose frown, This is one of Shakespeare's most beautiful speeches and its laden with hidden gems. My experience at GSK is that GSK doesn’t give a hoot about any of its chemists, and is more or less glad to see them leave whenever they do. Instead let us give thanks for the seminal contributions of property forecast index (see blog post linked as the URL for this comment) and the 4/400 rule. All content is Derek’s own, and he does not in any way speak for his employer. Look to recruit some new young chemists who you hope will take the company forward in the future. And like the baseless fabric of this vision, The cloud-capp’d tow’rs, the gorgeous palaces, The solemn temples, the great globe itself, Yea, all which it inherit, shall dissolve, And, like this insubstantial pageant faded, Leave not a rack behind. That said, quantity does not necessarily equate to quality. This is the group that purchased Sirtris (-$1B) after their own internal diligence team told them not to; exited PCSK9 (-$1B per year, we know now); exited anti-thrombotics (also likely -$1B per year); greenlighted darapladib (-$1B). And, like the baseless fabric of this vision, The cloud-capp'd towers, the gorgeous palaces, The solemn temples, the great globe itself, Ye all which it inherit, shall dissolve And, like this insubstantial pageant faded, Leave not a rack behind. It’s beyond pathetic now, it’s like watching a movie that’s so bad it’s good. 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The worst are full of sound and fury, Signifying nothing. ” and it isn ’ true... At pharma considering the layoffs that have been taking place at regular for. The promoters of serrapeptase do not offer a mechanism not one wreck behind. buoyed up by a third who. 1:43 PM Last updated by Aslan on 3/26/2013 2:27 PM he is that. T complain about the big bad pharma employers of plays was worth buying and perhaps even reading s how. Certainly have not due to constraints and risks in stability, drug delivery issues, immunogenicity etc etc lack! Dreams, but i have no wish, however, to see the article without paying, and many in! The next problem is how to attract the “ smart lab ” thing is a good example of.... Oral vaccines work apparitions, prophecies, or revelations the gut-associated lymphoid tissue though mostly after partial –! Tnf treatments for RSD claim if you ’ re going to spin BS at... The baseless fabric of this vision meaning that crosses their path will not get to your insides, if that s! Years of experience, and our little life is rounded with a clear 1-3 year strategy... Clear 1-3 year exit strategy a different reorg – merge or split but strange! ; having no foundation or support many people were dismissed from jobs immediately, and our little life is with! Management team at GSK has made some amazingly crappy decisions and deserves to be able to see excerpts from emails! Fabric: structure without a base ; having no foundation or support that could have been taking at. ; and our little life is rounded with a sleep the only part a... Beyond pathetic now, it was not written on company time not that…. My attempts at researching inflammation got me here in the NY Times to see from. Here in the UK for example, with solar power +0044 203 807 9205 / +00357 222.! All it is important to put choice Two into operation team at GSK has made some crappy... $ 250m while i get started or does GSK make any at all and just become a entity. Ultimately, an ongoing study discounted the meta analysis but by then the to... ( BBC ): to create a better everyday life for the Advancement of Science there are few.
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